DNA damage response, redox status and hematopoiesis

Heightened DNA damage response impairs hematopoiesis in Fanconi anemia.

Since its first description by Guido Fanconi in 1927, Fanconi anemia (FA) has become one of the best characterized inherited bone marrow failure syndromes. Numerous studies over the years have documented its clinical and biological features. It is recognized as being clinically heterogeneous and patients can have a wide range of developmental abnormalities. Many patients develop progressive bon...

DNA damage response and neuroprotection.

The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults. To cope with the consequences of DNA lesions which interfere with essential DNA-dependent processes including transcription and replication, cells are equipped with an efficient defense mechanism termed the DNA damage response. Its functio...

Radiation track and DNA damage

DNA Damage Response Pathways

ownload B4 is unusual among receptor tyrosine kinases because some isoforms can be efficiently cleaved at the a membrane to release a soluble intracellular domain. The cleavage product has high kinase activity mes to the nucleus. A screen for proteins that associate with the ErbB4 intracellular domain identified ate interactors including ITCH, WWP2, Nucleolin, and Krab-associated protein 1 (Kap...

Oxidative DNA Damage and Pro-inflammatory Response In Chronic Exposure To Cement Dust